Doc's heating up.
Get him some Waifu-pills stat!!!
Edit: As much as I'd rather see it happen, I think for Paradox to ignore the history of Vampire after all this time would be a commericial mistake in the short-term. I would love to see them re-imagine Vampire with touches of familiar names and ideas without all the baggage.
Vampire the Requiem says 'hi.'
Seriously, they already tried changing up the mechanics to enforce a personal horror experience. It went over so well that Old White Wolf went out of business and its IP was bought up by Paradox.
It took Onyx Path releasing the "Greatest Hits" inspired V20 that pretty much ignored the entire "Revised" era for a cleaned up 2e with less focus on the metaplot to actually get the Vampire line popular enough again for Paradox to create a NuWW subsidiary and consider making a new edition.
Then NuWW went and made the exact same mistake that killed White Wolf last time. Based on some polling done over at Onyx Path and only about a third of the current VTM players who responded are planning on switching over to V5. It could very well be more divisive for its base than 4E was for D&D.