The internet is now old enough that we can have 14 year old thread necros. Wow.
More recently, The Last Kingdom looks very much like an rpg. The main character has no loyalty to anyone except the latest hot chick, he defies kings and yet somehow retains his head, he neglects his family in favour of fighting and loot, he has a long-term goal which he never gets around to pursuing and if he does the GM pulls out a bunch of NPCs never mentioned before now to stop him, and he's accompanied by a team of misfits from a dozen different backgrounds.
Been watching season 4 and was thinking just how much this show feels like an RPG as well. Guy always has a whole party hanging out with him--even a priest and a war nun--and they're always storming castles or fighting entire freaking hordes of Vikings and stuff.
One show that was already mentioned, but without details, that would definitely work as an RPG is Dark Angel.
Characters would be escaped transgenic mutants born in a lab, without a name, identified only with a barcode at the back of their neck, marking them as property of Manticore. Now they have to fight in a dystopian biopunk future where they're hunted down by the secret organization that created them and the public that's slowly discovering their existence hates and fears them. But they have cool abilities and military training, giving them an edge over ordinary humans.
The show itself practically setup the entire rationale for how transgenic characters other than the show's protagonists could exist in the setting and be loose in the world (they all escaped and there's hundreds of them!). So you don't even have to bust your head trying to come up with excuses for how to play characters other than the show's protagonists and what type of motivation they would have for "adventure". And there's different types of transgenics so a lot of detail could be added to character creation for choosing transgenic enhancements and such.
There could also be ordinary humans as support characters as well, but those would probably be NPCs.