No.
Gender-fluid, Race-fluid, Class-fluid characters in a GM-less game. Written on butterfly-wings and rose petals.
With an intro written by Wil Wheaton and/or Matt Mercer. Summon Divyansh to get the hipsters all H'ded.
Men would have lower Will & Fort saves than female characters because #BendYourPenis.
Intimidation becomes the sole social skill allowing characters to 'shout-down' kings, a Tarrasque, and the Gods.