You woke up different, changed, by unknown forces.
I can smell the politics coming of this.
No politics so far actually. Beast was supposed to be the metaphor for being Trans, but this one was headed by Dave Brookshaw before being passed over to another bloke whose name I can't remember. There's been no heavy handed politics of any kind.
Edit: To add further, the big thing about Deviant is You didn't want to be what you are now. Out of the 5 Deviant "Origins" only 1 sought out it purposefully and even then didn't end up the way they originally planned to.
And since the Conspiracies can be literally anything, in terms of organized groups... there's no heavy handed political leanings one way or another, since you can have the Super Leftists Pagan eco group that decided you were going to be a host for a nature spirit, versus actually being descended from a Nazi super soldier program.
It seems like typical WoD material. A lot of mood creation, the books look great as usual, but what do you actually do in a game? It seems thematically interesting, but also made for a GM to go into full 'frustrated novelist' mode and ramble on about the dark mood of the game with the players being either railroaded by the GM or otherwise clueless what to do. It doesn't seem to be made for playing, but more for telling a scary story by the campfire holding a flashlight under your face.
Basically you fight the Conspiracies that helped create you. There are two types of Deviants, "The Devoted" and the "Renegades". This book is dedicated to playing the Renegades with plans for Devoted getting their own supplement further down the line. All of your goals are going to be wrapped up in your two defining attributes.. "Loyalty" and "Conviction" they both go to 5. Every dot of Loyalty you have, is someone you love, someone you want to protect and keep safe. It can be a pet, another human, or even another Deviant in your group.
Every dot of Conviction is someone, or some place, or something you want to get revenge on, and want to destroy.
You get your moral degradation to unplayable character status if you lose all of your loyalty and conviction dots. Like you would if you lost all your Humanity in Vampire, or all your Wisdom in Mage. You lose those dots when you fail to follow through on your loyalty or Convictions. Loyalty person in trouble? Better go help them. Chance to pursue your Revenge? Better go after it. Renegades start with 1 loyalty dot and 3 conviction dots. If a Renegade achieves more Loyalty than conviction, they enter a state known as "Guardian" where most of their disadvantages from their abilities are lessened.
Players and the GM create the conspiracies that created them, together... and all the Conspiracies are supposed to be intwined like an incestuous family. The Deviant whose a cyborg finds out the Head Scientist in charge of the black ops Military program that made him, is also a member of a secret occult group that bound the essence of a shadow spirit into the other member of his group. The occult group is how the scientist "enlightened" his mind and figure out how to make man and machine viable in the first place. The occult group is regularly provided the drugs they need by the Street Gang who sold out the third party member to the Corporation that created them.
Devoted by the way, those loyal to the Conspiracy that created them, reverse their two virtue traits... They start with loyalty 3 and Conviction 1. If they end up with more Conviction they end up in the state of "Fury" which has all the benefits of the Guardian Status from Renegade... Guardian and Fury are also not forever statuses, you can lose them and regain them as the story goes on.