For cyberpunk I tend to advocate using homebrew fluff over a savage worlds rules setting. The problem with the established cyberpunk RPGs, in my view, is that they are too tied to mirrorshades era cyberpunk. The setting is compelling, but at times I feel like I'm walking through a history book of the future. The fundamental pillars of mirrorshades just aren't tangible anymore for most people born in the 1990's. The Zaibatsu turned out to be horribly inefficient ways of running companies. The net went from a wild west into a much more corporatized and controlled tool for enhancing reality rather than replacing it with a cyberworld. Japan kind of collapsed. The wild conspiracy era of the 1990's made sense when we didn't actually have major threats to worry about. Cyborg implants are coming around, and shockingly they don't really mess with your soul.
In return, I actually feel like the modern world offers a lot more potential for cyberpunk. As the economy becomes more data and tech driven, industrial espionage is going to become increasingly important. Also, data security is becoming harder every year. It makes sense for companies to turned to closed off intranets. Right there, you have a reason for people to be breaking into places. Heck, the massive Target hack happened because someone sniffed out a backdoor through a small time ventilation company. There's a ton of threads you can pick up on and turn to 11 to create a relatable cyberpunk world. You still need to create an "adventuring paradigm," but that can be solved through going full noir and focusing entirely on planning, legwork and avoiding combat for the most part. The other option, (what I do) is have a situation where the government is encouraging ruthless competition, so as long as no bystanders get caught in the crossfire, they don't care what corps do to each other.
This is especially true for campaigns set in Africa or the Middle East these days. The Democratic Republic of the Congo is basically cyberpunk come to life. Companies fighting over territory, coopted governments, growing importance of tech. I'm currently running a campaign centered around Kinshasa and it's really easy to have plausible answers why the police don't care if you and a corp's security team are getting into firefights. Industrial espionage makes a ton of sense when billions of dollars in minerals are on the line. Nairobi, and it's booming tech center, also offers a lot of rich potential. Companies have already turned to the African continent to do testing they otherwise wouldn't be able to do. It doesn't stretch plausibility to think that this could turn into a booming biotech industry, with all the ruthless competition that could follow.
I can post my setting if people are interested, and I know it's not the best answer as OP was looking for a system to plug into, but for young'uns like me, there's a lot more potential for relatable cyberpunk settings in the real world, vs the 1980's view of how things would be.