Well, here's my idea. At the moment it'll be me, a first time DM, and two players, one beginning, one intermediate. I think I'm going to make this basically a learning campaign, one strictly for building your character, not much story, mostly action. This will help the players learn the process of rolling and role playing, and help me get a feel as DM of how they want to play.
Since there's currently only two players, I'm going to have them start out as already good friends, and I'm going to have an NPC that they've never met join them and the adventure will start from there. I'm thinking Fantasy Earth/Middle Earth type deal for a setting.