Who are the inhabitants. I'll go for the obvious question...
What is their culture?
I'll happily work it out, but this implies that I know what the local environment is, the rough technological level, the sorts influences that shape and develop traditions and taboos.
If you are talking fantasy, as I think we are, and vaguely D&Dish 'anything goes' fantasy, I'd think doing something interesting like pushing forward a non-traditional race as primary would make for an interesting idea for development.
Say we move Orcs from the tribal nomads into cities. Make the community originating in a settlement that was occupied by both Orcs and Humans in roughly equal numbers. As time moved on, a caste structure of sorts arose, with Orcs taking on jobs as guards and warleaders, along with less pleasent jobs involving heavy labor, while humans took on religious and beaurocratic services (trade and the like). Warrior castes are often the dominant one in such cultures, with religious castes falling a close second (and over a period of time switching places as the surronding lands grow ever more peaceful, often due to expansion as simply becoming too big to fuck with is a powerful deterant to most attackers).
So, the Orcs have the highest caste on lock, and the humans normally would have the second caste, and an uneasy racial tension, quite at odds with such a longstanding situation develops? Why? Because we forgot to include the hybrids, the Half-orcs who would presumably be the dominant population of such a city after a long period of time. Furthermore, as a bridge between the two races, Half Orcs would be the real powerplayers in the religious caste, and as a race would be found in all the castes in lesser numbers.
If this is in line, I'll keep going.