I don't know what "D&D" even means anymore. If we're talking about "system" - I'm open to checking out any system in play. If we're talking about settings, "D&D Settings" from WotC have completely skyrocket-jumped every shark imaginable.
IF I were to GM a D&D d20ish system, anything 3e, 4e, or 5e is a non-starter. If 6e comes out... I'll do my due-diligence and evaluate it, but I have little faith that 6e, when it arrives will be anything that interests me. If I were going to GM D&D - it would be 1e/2e and I'd seriously consider doing OSR.
In the meantime - I've got PUH-LENTY to run for the next decade: Talislanta, Deadlands, FFG Star Wars, MSH, Savage , but I'm eyeballing Mythras/RQ6e, Warhammer (and if they drop the Original World it's a SHOE-IN, otherwise WHFRP 2e), Cyberpunk Red.
I mean... realistically? "D&D" has become almost provincial in it's mainstream iteration. OSR is more innovative and useful than 5e imo mechanically by dint of flexibility. And while I'm a system's wonk, I love good settings. I'm happy to convert what I want to other systems, if it suits me. Right now - WotC gives me nothing that I want that I don't already have. Sad to say. But it's true.