Jesusfuckingchrist, what a fucking stupid thing to write.
The indigenous people of the Americas built cities, cultivated land, managed game, and participated in trade networks which spanned the continents. The Americas didn't become "wild" until European diseases killed most of those people off, in greater numbers than the Black Plague, which left post-Roman Europe "wild" for the same reasons.
The Americas were a post-apocalyptic landscape by the seventeenth century, with immune invaders scavenging the ruins and subjugating the survivors. It's a world haunted by ghosts.
You are correct in the assessment that the Native American tribes built great cities and had vast civilizations, but by the time the English landed in Virginia in 1607, disease had pretty much decimated all that. Just like you said.
And considering the fact that my campaign is centered around a historical fantasy version of Jamestown, well......
Players would start out at Level 1 and be English settlers/adventurers on contract with the Virginia Company of London and the English Crown, and the biggest threat isn't the Natives or even the wild animals and monsters lurking in the Virginia woods, but rather the Spanish, who are at the height of their colonial empire's power and are willing to plunder the fledgling English colony. After all, Jamestown was initially built as a fortified village. And the reason why it was built like a fort was to keep the Spanish out, not the Natives.
In fact, the English really didn't see the Powhatan and Rappahannock people as a threat until 1622, when Opechanacough, brother of the legendary King Powhatan, became the new chief of the Powhatan and declared open war on the English. The English were caught by surprise because they were so concerned about the Spanish (as well as the profits of tobacco farming, as Virginia was established as an economic venture) that they didn't really pay attention to the fact that they were royally pissing off the Powhatan and once John Rolfe and Pocahontas left for London, all bets were off.
Jamestown survived because it was well-fortified, but the outlying farms and settlements that had sprung up around the Tidewater during the 1610's and early 1620's were largely decimated by the Powhatan.