I'm looking for a good replacement for the World of Darkness games because certain things about the lore and setting urk me. I love the different factions like the Camarilla and Sabbat in Vampire and the different Clans in Vampire as well. I'm seeking a game/system that can encompass the whole of the entire WoD setting including Vampire, Werewolf, Mage, Changeling, Mummy, Wraith, Geist, Hunter, etc. meaning that all these kinds of characters can be explored/played as and encountered as NPCs. It always bothered me that WoD was so compartmentalized where vampires would never team up with werewolves or mages, etc., even if the story could allow for it due to narrative reasons.
So my *real* observation about this - as I've had with this very question that has come up many times recently: You seem to know what you don't want (WoD metaplot), but you like all the high-level elements within the WoD.
These elements exist in literally dozens of settings with entirely different backgrounds to those elements - so are you wanting to stick with the WoD system?
Because otherwise just pick a gaming system you *really* like - and make it all up. As posted upthread, Chronicles of Darkness's system (NWoD) and it's 1e books were pretty metaplot free and ALL those elements are obviously in play and it's designed for them to work together as you see fit. So a lot of the heavy lifting is done for you.
If you're looking for a new system that also has those elements... that's a pretty broad question. Everyone here will post their favorite system to use, but without knowing if you're trying to emulate WoD directly, different systems will weight a different emphasis to these elements. And it also depends on how much customization and work you're willing to do to pull it off.
If you're willing to go full-on scratch-build I'd suggest a universal system: GURPS, Savage Worlds, d6 etc. If you're wanting to go with something thematically designed for Horror(ish) games - Cthulhu, Nightbane(Palladium), Nightlife.
If you want to repurpose an established system: I'd suggest as others here have: Cyberpunk2020 (Interlock), Marvel Super Heroes (FASERIP), or anything else that you're passionate about personally.
Otherwise- I'd fall back to Chronicles of Darkness.