Mutants and Masterminds 1e was the first supers game that didn't fizzle after 2 sessions for my group. I ran a 3 year long campaign that started at street level and ended up just shy of cosmic by the end. We've revisited the setting we built a couple times, although we've moved over to M&M 3e, and plan to do another campaign at some point.
Both Aberrant and Necessary Evil I love for the settings alone.
Recently we've gotten into Tiny Supers for quick one-offs where we want to have a night of super hero fun without any commitment to anything. Usually happens when one or more people can't make it for the regular game.