I think the OtE rules would be an excellent match for Dresden Files - the "classic" Over The Edge is more than a little Dresden-like to begin with. Albeit you might need some better rules for magic - I can't remeber how good/thorough they were?
If I remember correctly one of the old Over The Edge-sites (Lareau-something?) had links to places where the rules where used for both a post-apocalyptic game and Star Wars.
It's not more than a week ago I talked with my group, and the most die-hard 3.5 rules expert stated, that he considered the OtE rules the best simple/easy rules around, based on our past Over the Edge campaign.
And yay for Atlas Games giving Over the Edge some attention once again!