North America will be interesting. Just forget everything you know about native Americans, under the standard fantasy model, North America will be organized into a bunch of fantasy kingdoms, let's make Manhattan Island into the equivalent of Waterdeep, there are a bunch of coast hugging sailing ships that play their trade up and down the coasts of the Americas, let's call this the Republic of Manhattan, it is a city state with some arable land area for growing food for its populace, its territory includes the entirety of Long Island, and what in our world would be Westchester, Orange, Rockland counties and much of northern New Jersey, their are farms villages and castles in this region, there are a mixture of fantasy races here, but the population is about 70% human, an elven kingdom is nearby in upstate New York, ships travel up and down the Hudson River (here called the West River) to trade with the elves.
There are dragons that live in the Adirondacks and in the Appalachians. Everywhere in North America, the Common language is spoken, it is about 70% to 80% similar to English, though the actual English don't know why! The people of North America worship a pantheon of gods and goddesses that are similar to those of the ancient Greeks, Roman's, and Norse gods, the pantheon is more disorganized than those with each deity going his own way, with no real equivalent to Zeus or Odin to head the pantheon. Since the Spaniards colonies in this New World aren't as extensive as in our history, the English get in on the trade a bit earlier, as the Spaniards have no control over who these fantasy kingdoms trade with.
Oh did I mention, there is lots of copper, silver, gold, and platinum here, much of it coined and used as a common medium of exchange, these precious metals are more valuable in Europe and much of it will flow across the ocean to Europe causing precious metal inflation.