Of the people in Wheelchairs who have played in my D&D or Traveller games, and there have been a few, absolutely none of them wanted to play a character in a Wheelchair. They opted of course to play Heroes, and Wizards, and Fighters and Rogues, without any disabilities, instead whenever possible, just like the rest of the player, they wanted to play healthy and strong larger than life heroes.
Also WOTC is not original in this. GURPS has had disadvantages since the 80's, and you could play a guy in a wheelchair, (Professor Charles Francis Xavier, for a guy in one of my X-Men games), which would give you more points for other skills or advantages.