Who's the target player?
There are numerous board games that use this dice pool system (Betrayal at...) but they are not regular d6s and instead have 0, 1, or 2 pips = 0, 1, 2 successes. It's super easy for casual players to learn. The numerical probabilities are not obvious to calculate, but they are intuitive. It is immediately obvious when you roll if you've succeeded or not.
d6+skill vs target number requires arithmetic. Even basic arithmetic can throw people off. Dice + skill vs target number works better if you're using d10, d20, or d% because those are easier to calculate odds mentally. It just easier to count by 10%, 5%, or 1% in your head than 16.67%
So, I would favor the dice pool, as long as skill doesn't got crazy high like 10 or something. Rolling 10 dice can be a chore.