I have to admit that I found the removal of alignment a novel idea with Arcana Unearthed and Iron Heroes, but there were still themes of conflict which embroiled the characters and the settings. Even in the game I am playing now By This Axe I Hack alignment is virtually unheard of. However the game does provide rules for campaigns in which the conflict of Order and Chaos is a major part of the world, and I think it would be cool to have a campaign like that (on occasion).
At the same time, however, it would be nice to see systems that aren't reliant on alignment but on other motivations (rule defined or player defined), and where Player Actions identify their "alignment" instead of a filled in slot on a character sheet.